Djakou started studio practice in 1998 after six years of study. The same year, she became an instructor in the only art school (Intitut de Formation Artistique) in Central Africa at Mbalmayo, Cameroon. There, she successfully introduced the "Material Technology" course into the school's curriculum. In 2004, she was employed by Centre d'Art Appliqué of Mbalmayo, Cameroon as a ceramist and chief manager of the ceramic studio with whom she had local and international exhibitions. By 2011, she became the vice president of the craft association of her local government for 3 years. In 2013, she created a ceramic group DECERAM where she realized a lot of commissions. Coupled with many years of studio practice, Djakou Kassi Nathalie has worked with many renowned artists in their studios and obtained many distinctions, awards, and prizes in and out of Cameroon. She also trained many young artists in Cameroon and Nigeria.

Djakou Kassi Nathalie moved to Nigeria in 2015 to continue practicing her art, she has had many exhibitions including the two-man shows twice with Ato Arinze, titled " BEYOND FUNCTIONS " Since 2015 she is a member of Society of Nigerians Artists (SNA) and since 2020 member of Sculptors Association of Nigeria (SCAN) she also participated in many other group shows with many galleries in Lagos and Abuja.